Risk factors for contact urticaria manifests itself as redness, swelling and swelling by immunological and non-immunological means after contact with a foreign substance. In reactions that do not occur through the immune system, chemical substances directly stimulate the allergy cells and cause the release of chemical mediators from these cells.
This type of non-immune-mediated contact urticaria (hives) is the most common post-exposure reaction and does not require prior sensitization. The symptoms of this type of urticaria after exposure may vary depending on the place of exposure, concentration, mode of exposure and the properties of the substance itself. In this article, we answered the question of what are the risk factors for contact urticaria.
Risk Factors for Contact Urticaria
In contact urticaria that is not mediated by the immune system, it is the sudden release of chemical mediators such as histamine, which were previously stored in allergy cells, after contact with foreign substances. It is predicted that a mechanism mediated by mediators such as prostaglandin may lead to this.
Contact urticaria mediated by the immune system is less common but more severe; It may even progress to allergic shock. The immune system must be sensitized by this foreign substance and produce IgE. In this type of contact urticaria caused by IgE, foreign substances must have been encountered by the skin, digestive system and respiratory system before and antibodies must be formed against these substances.
One of the important points to be considered in contact urticaria caused by the immune system is that these reactions may occur due to cross-reactions. Patients sensitized to an allergen and may cross-react to other allergens containing the same or similar antigenic properties. For example, patients with latex allergy may experience the same complaints with various fruits and vegetables such as banana, chestnut, avocado and kiwi. This puts patients with immunological contact urticaria at risk for allergy to multiple substances.
The risk of being seen is higher in those with complaints such as atopic dermatitis or allergic rhinitis asthma.